Research on Author Bram Stoker Paper Example | Topics and Well Written Essays - 1750 words

On Author Bram Stoker - Research Paper Example To be specific, the amalgamation of history, imagination and horror raises the novel Dracula to new heights of readership, and the novelist to popularity. Thesis statement: Bram Stoker’s writing style, with unique themes, symbols, metaphors, imagery, and character types, is symbolic of the Gothic horror genre in English Literature (special references to the novel Dracula). Short biography Bram Stoker was born in the year 1847, Clontarf in Ireland. His childhood was not so happy because he was forced to be bedridden due to sickness. Sue L. Hamilton states that Bram Stoker’s experiences (say, sickness) in his childhood helped him to be imaginative and creative as a writer (Hamilton 8). When he entered the Trinity College, he was able to overcome the past troubles. For instance, he proved himself as brilliant in athletics and academics. After graduation, Stoker entered the Irish Civil Service and remained as a civil servant for the next 10 years. His entry to the civil ser vice did not hinder him to make progress in his literary career. Besides, his relation with Henry Irving helped him to be in the limelight of Lyceum Theatre in London and his contribution to drama criticism was noteworthy. But Stoker was not ready to give up his ambition to be a writer and he decided to write novels. As pointed out, ill health in childhood and family influence in the early stages of life deeply influenced him and he was attracted towards horror novels. Carol A. Senf opines that Bram Stoker’s curiosity in learning science and horror maybe deeply rooted in his family background (Senf 50). For instance, one can easily identify that Stoker’s novels represent the horror (Gothic) novel genre in English Literature. Some of his novels are: The Snake's Pass (1890), Dracula (1897), Lair of the White Worm (1911), etc. After the marriage with Florence Balcombe in the year 1878, Stoker moved to London and worked as the manger of Lyceum Theatre, London. In London, S toker was able to be in the elite circle of writers. This relationship with writers like Sir Arthur Conan Doyle helped him a lot to fulfil his ambition to be a writer. Meanwhile, Stoker decided to conduct a world tour and visited the United States of America. The world tour boosted Stoker’s craftsmanship as a writer. For instance, in the United States of America, Stoker was able to meet Walt Whitman, one of his favourite writers. Besides, the American tour inspired him to select the same nation as the background of later works. Generally, Bram Stoker’s short stories and other novels apart from gothic novels are less appraised by critics. For instance, the novel Dracula is praised as one of the most important gothic novels in English Literature. Due to stereotyped characterization and less importance given to vividness, Stoker’s other works are generally less accepted. In addition, the high content of melodramatic elements that can be seen in Stoker’s nove ls and short stories reduce the scope of vivid characterization. But the craftsmanship shown by Stoker in describing places proves his craftsmanship as a novelist and short story writer. Bram Stoker passed away in 1912. Bram Stoker’s life history and his journey from Scotland to England are noteworthy because his profession as a theatre manger did not harm his ambition to be a writer. Instead, his profession boosted his ambition to b

Adam smith vs Karl marks philosophy economics contribution Essay Example for Free

Adam smith vs Karl marks philosophy economics contribution Essay To begin with, Smith came up with the concept of the ‘invisible hand’ (Communist (1848)). This concept was to explain that seeking self interest is not necessarily bad but it sought to explain the reality that people tend to act in their own self-interests. When individuals pursue their self interests, they promote without their knowledge the good of the community at large and so it can be said that an individual who wants to maximize their revenue maximizes the revenue of the society too. This liberty to customers to buy freely what they want and for the producers to produce what they want without any pressure enables the market to settle on a product distribution and prices that are beneficial to all individual members of the community. This liberty to both producers and consumers and the greed to maximize their interests, drives them into a behavior that is beneficial to all in that particular community. Due to this, producers are forced to employ methods of production that are efficient with an aim o maximize their profits. This leads to low prices that are meant to out do their competitors and this forces investors to go for firms that wants to maximize their profits and hence this works as mechanism of balancing. The invisible hand concept acts as the root of modern economics. A good example is the general equilibrium which states that if the economic forces are balanced in the absence of external influences, then the economic variables will not change. This requires that everything in the market beginning with pricing to production be controlled by the players in the market but not by other forces. These external forces may include among others the regulations that are imposed by the government or other organizations that may have a say on the market. According to the general equilibrium, when the prices are very low, then there is surplus supply and when the prices are very low, then there’s a shortage in supply. As a result of this, the situations tend to control themselves without the need for any regulator from outside. These outside forces in the market slow the rate at which the economy grows and they also lead to infancy in the division of labor. As a result of that need for self improvement, efficient division of labor is realized as well as improved efficiency in the economy. This concept is very much in use even in today’s economy . The modern market structure borrows greatly from the earlier ideas of natural monopoly by Adam Smith.( The Poverty of Philosophy human nature) The division of labor Division of labor is a clear indication of qualitative step towards increased productivity and so it acts as an engine that drives towards realization of economic progress. Smith realized that labor division and for that matter labor specialization would improve greatly on the concentration of workers on the duties they perform. This concentration would come as a result of doing a single task many times or repetitively. The need for improvements in productivity of the work force is said to be the root cause for labor division. According to Smith, labor division can lead to increased productivity. This productivity from the workers can be attributed to specialization in one task since specialization leads to greater skill on their particular subtasks compared to what would be accomplished by the same number of workers performing a broad task. For maximum productivity from workers, skills that they have should be matched with the corresponding equipments.   Most of today’s increase in productivity can be attributed to the matching of technological, human and physical capital and mostly in the manner in which they are organized. This means that laborers need to be equipped with the right skills so as to be effective in what they do compared to when there would be no job specialization and hence anybody could perform any job. Todays economics has borrowed greatly from these ideas from Adam smith. Many organization have realized the need to equip their employees and some even hire unskilled ones but pay for their acquisition of skills. Another outcome of labor division according to Adam smith is minimization of time that is wasted by employees when moving from one task to the other. A lot of time is wasted when people keep on relocating and this proves expensive to the company in the long run because they have to pay the employees. Through labor division, this time wastage is minimized . The modern concept of scientific management borrows greatly from Adam Smiths ideas .Scientific management emphasizes on the connection between activities and the transformation that occurs within the process. This is also supported by William Petty who notes and demonstrates its importance in the construction of Dutch ships. He admits that people with a particular task to perform had discovered new ways of doing their work which were later observed and justified by political writers on economy. (An Inquiry into the Nature and Causes of the Wealth of Nations (1776) specialisation) The wages of labor Wages of labor are dictated by mostly by the availability of job vacancies and also by the availability of workforce. When there are many workers and the available vacancies are few, the amount of money the workers are paid usually fall. Likewise, when employers compete against one another and the labor supply is limited, the wages paid to the employees usually rises but its worthy noting that this process is made possible by unity among laborers and masters. This kind of unity enables laborers to come together and stop biding for jobs against each other hence making the employers increase the wages paid to them. Likewise when employers come together in unity and stop binding against each other, the wages fall. However, in places where the amount of labor is more compared to the amount of the amount of revenue that can used to pay for waged labor, the competition among the employees in greater than the competition between the employers. Smith argues that the amount of revenue must keep on increasing constantly compared to the amount of labor so that wages may remain high. Profits of stock too have an impact on the wages because the more money is spent on compensating labor; little is left for personal profit. This is clearly shown in countries where competition amongst employees is great compared to competition among employers, profits will be much higher. Due to these views, Smith attacks people who are politically aligned and try to use their political influence to manipulate the government and other powers into their bidding. Smith feared that people of this class could form a powerful block and take advantage of their closeness with the authorities into manipulating the state into enforcing certain regulations meant to serve their interests against the general interests. These would maker other players vulnerable and have no say in the way businesses were being conducted. According to other people the level of specialization brought about by division of labor was externally determined but in the contrary, Smith argued that it was the dynamic engine towards economic progress. Surprisingly, Smith himself criticizes the division of labor arguing that it leads to mental mutilation of the workers hence rendering them ignorant and insular because their lives are limited only to doing a single task many times. These ideas by Smith are incorporated into today’s discussions on economic issues. Human capital is one of the discussions in which Adams Smiths ideas are used. Human capital is one of the four types of capital that were identified by Adam as being important for the success of a company. As argued by Smith previously, human capital and the productive ability of the labor force is both dependant on the division of labor. It’s worthy noting that human capital includes skills, dexterity, and the ability to make the right decisions and human capital can be acquired through informal schooling and on the so called on-the-job training. These acquisitions of skills aimed at improving the effectiveness of the workforce are still practiced today by ma ny companies. (An Inquiry into the Nature and Causes of the Wealth of Nations (1776) productivity) Adam Smith vs Karl Marx Both Adam Smith and Karl Marx shared a common idea and this common idea was their praise for capitalism .These two early pioneers of modern economics agreed that capitalism was the key in unleashing the productive powers. This argument stated that for the employees to be more productive, they needed to be subject to their bosses or seniors. If the employees were left to work at their own leisure these two men agreed that their productivity would be minimal and as a result, their employers would incur big losses. This created the need for competition among both the employers and the employees as well since this would keep these two parties on their feet through out. But despite these similarities in their in their views, there was differences in their ideas as well. Marx and Smith both seem to agree that capitalism is the ultimate driving force in profit maximization .New profits and value added, they seem to agree came as result of the employers paying the workers the exact value that is in the market for their labor capacity. But the sad thing was that in most cases, the market value of the goods which the workers produced exceeded that market value. This clearly means that the employers were making maximum profits while paying little to their workers. Both Marx and Smith agree that     there are different types of capital and they play different roles during production. Production Capitals include things like land, natural resources or raw materials and lastly technology. All the above named different classes of capital were dependant on each other in production. These two men seemed to agree also that social relations of production should not only be made up of relationships between individuals but rather should be between large groups of people or certain classes of people. These two men had the same idea of a free market. They described a free market as a market in which all prices of the goods that are on offer are decided by mutual consent between sellers and buyers   and also one   that did not mislead both the sellers as well as the buyers. They both argued that these two major people in the market, the buyer and the seller, should not be forced into making decision by an external party. The relationship between these two players should not be manipulated by any one but to the contrary, it should be left to obey the natural law of supply and demand. The difference between free and controlled markets is that   controlled markets are controlled by external forces These forces mostly refers to governments which may directly or indirectly try to have control of prices or the supplies in the market. One area where these two men seem to differ is their idea of job specialization. Smith advocates for specialization for jobs among workers. He argues that laborers who were assigned too many different duties were less productive than those who were assigned a specific task to perform day in day out. He says that this leads to efficient usage of time and it seeks to save time that is usually wasted by workers when moving from one task to another. But to the contrary, Karl Marx disapproves this idea arguing that job specialization could result to workers with more poor overall skills. This, as he says would be brought about by tendency of people to resist change. He also says that when people perform one task repeatedly, it may lead to boredom and make them less enthusiastic about their work. He describes this whole process as a kind of alienation. According to him, the more workers become specialized and do the same thing over and over, they later become totally alienated. Marx goes ahead to argue that division of labor brings with it spiritual depression to the workers. This means that the workers perform their duties feeling as if they are being forced other than doing out of their own will .This greatly lowers the morale of the workers and as a result lower their productivity. Physical tiredness or fatigue can be brought about by job specialization as Marx goes ahead to argue since they no longer feel like human beings but they feel more of machines. Contrary to the idea of Smith, Marx believes that fullness of production is very essential to human liberation goes on to say that he would accept the idea of a strict division of labor as a temporary necessary evil. These views can be said to be in total contrast to those expressed by Smith. Smith on his part believed that any business was a collection of inter related tasks that were aimed at solving a particular issue. So as to effectively do this, Smith argued that the workload should be divided into simple sets of tasks which could be done effectively by workers who were equipped with special skills for doing that particular job. It’s worthy noting that Smith, despite his advocating for division of labor, he does not advocate for achievement of labor division at all costs. It’s worthy noting that in contrast to Smith’s view which were only limited to functional domain only and were made up of activities that were direct in sequence as far as the manufacturing process is concerned, modern processes are very inclusive. It was as a result of his ideas that labor division was adopted. Today, we can clearly say that much of today’s practices in the job markets have bor rowed greatly from the ideas of Smith. In all organization, there is job specialization. This has led to the rise of departments in many organizations and each department is allocated certain workers who are in most cases equipped with certain skill to enable them perform specific duties .The sense in this whole exercise as argued by Smith is that it saves a great deal of time that could be wasted by employees when moving from one task to another. This proves very essential since no employer will want to waste his money employees without maximizing their productivity. However, it is good to note that Smith admits that seeking self interests is not always good. All he tried to do was trying to reverse believe that self interest is generally bad. He also intended to bring to the light the idea that wile human motives are selfish and greedy; the out come of these human behaviors would bring benefits to the whole community at large. This is the direct opposite of the ideas that Marx had .In his arguments; Marx says that the major struggles are always between the producers and those who work in the industries. Another of his greatest contribution to modern economics was his sharp distinction between the two types of division namely social and economic division of labor .If these two labor divisions are conflated, it might look as if labor division is inevitable rather than being constructed socially and influenced by power. (Adam Smith, An Inquiry into the Nature and Causes of the Wealth of Nations (1776) Karl Marx, The Poverty of Philosophy). References Edwin G. West, (1976)The Man and His Wor

Safety in plastic manufacturing

Safety in plastic manufacturing INTRODUCTION: Plastic manufacturing is becoming one of the most important fields in manufacturing (Makin 1987). All manufacturers are trying to reduce their cost by putting plastic into their machines or computers. Plastic Manufacturing started from producing combs and buttons till it reached different fields of production such as: automotive, medical equipments, aerospace, construction and consumer goods as well as toys and packaging. The most important threat that has been facing the advance of this technology is health and safety. Safety in plastic manufacturing is critical because you deal with different areas such as: the machinery, raw materials (generally petrochemical materials) which are mostly flammable and lately there has been environmental issues of concern arising from the manufacturing of plastics thats why It needs to be considered during the design phase of a factory before starting the manufacturing phase. With more and more automation and advanced machinery being applied to this industry, and greater application of new technologies being implemented with increased capability for providing flexibility to the process and operations, greater attention has to be given to safety. This research aims to capture what level of safety is there in plastic factories. And what it lacks for and what is needed to implement health and safety inside these factories and protect the workers and the owners of the factory in addition of comparing the cost of a safety program in a factory to the money spent in case accidents happen because of the low level of safety. The study will briefly review the impact of this industry on the environment and the importance of recycling to cut-down these impacts. Studies have been conducted in different industrial countries like: The United kingdom and The United States of America and comparing that to an industrial developing country like Saudi Arabia. KEY QUESTIONS: There are several questions to be exploded in this topic of research because as mentioned earlier safety in plastic factories is critical because it is attached to different sectors like: machinery, raw materials, and environmental issues. So the main question can be: How to implement a safe environment in a plastic factory? This main question can be specified by using the following questions: 1- What are the most common accidents and injuries that happen in plastic factories? 2- What are the reasons that cause accidents in plastic factories? 3- Why is plastic manufacturing threatening the environment? What are the solutions to reduce this risks and accidents caused by this industry? 4- How can you develop safety in plastic factories in developing countries like Saudi Arabia? AIMS AND OBJECTIVES: This research will aim to capture the main reason of accidents in plastic factories and how to implement health and safety in this industry in all phases. These aims can be specified to the following: * Decreasing the risks that plastic manufacturing causes in the environment, and developing the ways to prevent pollution caused by this industry such as plastic recycling. * Cutting down the number of accidents during work by applying advanced safety plans and precautions in Saudi Arabia. * Analysing the most common accidents and their reasons and link them together statically. * Implementing computers and networks in emergency management inside and outside the factories. Generally, this study will embrace the ways of having a healthy and safe environment in plastic factories and how to reduce accidents and risk that are caused by this industry. LITERATURE REVIEW: In 1868 John Wesly Hyatt developed plastic material called celluloid he used it to substitute ivory which was becoming more expensive and difficult to obtain after improvements ,from that plastic industry was born (Bryce 1999). During the next 40-50years others began to investigate this new process and used it for manufacturing. During 1940s the plastic injection moulding industry became more popular because of the demand created for inexpensive mass produced products after the World War II. The makers of Bakelite, the first synthetic plastic called it the material of the thousand uses and used the mathematical symbol of infinity [à ¢Ãƒâ€¹Ã¢â‚¬  Ãƒâ€¦Ã‚ ¾] as a trademark (Bryce 1999). In general applying safety to your factory and keeping your workers healthy and safe does not happen by chance there are different things to be done from electrical and machinery safety to dust handling requirements for example: careful management processes, commitment throughout the organisation in addition to safety management including risk assessments, engineering controls, and emergency procedures and training. Good management processes in plastic manufacturing includes carefully evaluating raw materials and implementing controls such as containers, safe handling procedures and use of appropriate personal protective equipment, because as mentioned before plastics are petrochemical materials that must be dealt with carefully. It is always recommended to have a good communication with the raw material companies in case any information is needed. Prevention of pollution is essential too; it can be by controlling techniques for emission such as optimising processing conditions for h andling and mixing dry additives and storing of these materials. Health and safety associations such as Health and Safety Executive (HSE) work to improve safety in a wide variety of sectors in this industry. Firstly, machines new or old should comply with its regulations and meet the requirements needed. About the workers; government regulations in Europe and North America require that operators be protected from moving parts of machinery, while machinery parts that require a tool to open must be opened by trained personnel following appropriate safety procedures (British Plastic Federation 2009; Health and Safety Executive 2009). To avoid hand injury which is almost 25-50% of the total injuries in this industry according to the HSE statistics survey, robots and automation are implemented to protect workers from injury during manual handling although it is difficult to eliminate manual handling but they are trying to cut it down. Safety of using these robots should be encountered too because there are not reliable and safe 100%.There are several accidents reported from using robots and automation, the first robot fatality occurred in Japan in 1981 the robot stabbed an employee to death the employee didnt use the safeguards (Makin 1987). Nearly 80 accidents in blow moulding factories were investigated by inspectors from HSE during 1986-1996.It was found that 50% of these accidents happen because inadequate or damaged safe guarding about another 25% were because of defeated safeguards (Health and Safety 2009). To avoid these kinds of accidents it is recommended to: provide the right safer guarding and check it is kept in the position and working effectively. Plastics are created by refining common petroleum products the most common are crude oil and natural gas. Fire in plastics manufacturing may generate black acrid smoke and poisonous gases including carbon monoxide. The fires may spread quickly and be difficult to extinguish. Sources of ignition should be controlled by prohibiting smoking and hot work in high risk areas. A key to safe operation is safety awareness and putting safety as a priority at all levels, from the operator to the manager. Mr.Seeberg the safety director at Clariant says that workers will notice if their site manager or supervisor is only concerned with the output or is also concerned with safety (Science Direct 2009). Before safety training can be effective, top management must show a clear commitment and interest in safety. Some managers say that their major concern is that they do not have the resources to have a full time safety person in this case they can rent a safety supervisor in-order to reduce the cost. In general the employers duties can be summarised in: * Making the workplace safe without risks to health. * Ensuring the plant and machinery are safe and that systems of work are set and followed. * Giving the information instructions, training and supervision necessary for health and safety. The successful implementation of management system for both occupational health and safety and return to work programmes will result in positive change in business and safety cultures in the industry and there will be a considerable opportunity to reduce costs in manufacturing. The plastic industry faced a lot of threats in its beginning a lot of people tried to link it with cancer. The waste and littering caused by plastic products in the world especially in sea shores (Meikle 1995).Plastic bags are light weight and moisture resistant meaning that it can float in air and water easily and travel long distances. Every year more than six million tons of trash is dumped into seas and oceans more than 80% are plastic like plastic bags and bottles. Sea creatures eat the plastic thinking it was food which can cause their death, some blamed plastic bags for the death of kids by suffocation too (Clean Up 2009). To avoid plastic waste and cut from its effects high fines are applied now; in the USA the cruise ship Royal Princess was fined  £311,000 for dumping 20 bags of garbage overboard( British Plastic Federation 2009). In-order to face these threats plastic associations are implementing recycling in every home so the impacts of this manufacturing can be prevented. Most of the plastics can be recycled and has its own way of recycling, thats why in the bottom of every plastic product you can find the initials for its name and type like PP for polypropylene and HDPE for high density polyethylene as shown below in Figure(1). In the UK five million tonnes of plastic are used annually only 19% is getting recycled but it is planned to reach 25%by 2010.There are a lot of benefits from recycling plastic, to sum it up we can say: less used plastic, less oil used for plastic production and less energy consumed which will affect the plastic industry positively. REASEARCH METHOD: In this part I will introduce the methods used in this study and explain the techniques used and where this research fit into. Generally this research is a combination of both methods; quantitative and qualitative which is also known as the mixed method. Firstly, the quantitative method which mostly deals with numerical data to develop theories and hypothesis (Creswell 2003). In-order to obtain information to develop the safety in plastic factories we are going to design questionnaires and surveys to seek answers for a couple of question that will help us fill the gap. Some of these questions are open-ended and that is where the qualitative method combines. Secondly the qualitative method is a method of inquiry used for different scientific and academic fields, traditionally in the social sciences, but also in market research (Creswell 2003). It also investigates how and when a decision can be made we will make some interviews with workers, factory managers, and people from health and safety organizations. Usually in social sciences quantitative research is contrasted with qualitative for the purpose of discovering meaning and models of relationships. Although when it comes to their aspects of scientific investigation there is a difference (Creswell 2003), it is said that both are attached and help each other as Kuhn (1961:152) says large amounts of qualitative work usually been prerequisite to fruitful quantification in the physical sciences. Qualitative research is used to explore a phenomenon and form theories then we can test these theories by using quantitative research. In this research in-order to obtain useful information that can help in applying health and safety in plastic factories and have a safe environment, we will have around 200 questionnaires distrubted to different types of people who in this industry such as: workers, engineers, managers, etc. There will be interviews with people from health and safety organisations in the UK, like the Health and Safety Executive (HSE) and the Plastic Processors Health and Safety Liaison Committee (PPHSLC). Also there will be four factories from Saudi Arabia as case study and compare the safety of these factories to the safety requirements in the UK and try to develop the safety there to the same level in the UK. All the data taken from the questioners, survey, and interviews will be analysed by using SPSS to determine the relationships by manipulating factors thought to influence safety in plastic manufacturing. There are several studies done before in how plastic manufacturing is effecting the enviro nment we will see where these studies reached and modify their approaches. TIMETABLE: TASK DURATION Proposal Preparation 18Nov-1 Dec Literature Review 1Dec-1 March Fieldwork 1Feb-15 March Data Analysis 15 March-22 March Presentation 22 March-1 April Final Report 1 April-30 April CONCLUSION: As a conclusion for this study we will find the gaps in safety in plastic manufacturing and help having a safe environment by developing safety procedures and observe the threats that are effecting the environment. Also, the safety in plastic factories in Saudi Arabia will be studied, and determine what it lacks for and how can it be developed to reach the appropriate level of safety. As all studies in this field this study benefited from the relevance of previous researches and assumptions of many experts. The analysis of the data and surveys will show how much people are concerned about safety. Hope this study cans be effective in the development of safety in plastic manufacturing and helps other researches in the future in this topic to obtain what safety in plastic factories lacks. REFERENCES: British Plastic Federation (2009), Health and Safety [online] available from [21 November 2009] Bryce, Douglas M. (1999) Plastic Injection Moulding. Clean Up Australia Ltd (2009) Plastic Recycling Fact Sheet [online] available from [22 November 2009] Creswell, J.W. (2003) Research Design: Qualitative, Quantitative, and mixed method approaches. Cross Plastics (2008) Domestic Recycling Symbols [online] available from [30 November 2009] Health and Safety Executive (2009) [online] available from [17 November 2009] Meikle, Jeffry I. (1995) American Plastic a Cultural History. Kuhn, T. (1961) The Function of Measurement in Modern Physical Science Makin, P. (1987) Safety in Advanced Manufacturing, Journal of Proceeding of the Advanced Manufacturing international seminar 14,(1) 1-4 Markarian, J. (2008) Worker Health And Safety in Plastics Compounding. Journal of Plastic Additives and Compounding [online] 10,(1) 26-29.Available from [28 November 2009]

Factors that Negatively Effect Fetal Development Essay -- essays resea

Factors that Negatively Effect Fetal Development Pregnant women that smoke cigarettes on a daily basis can greatly harm their fetus. The Tobacco smoke in cigarettes greatly reduces fetal growth through the presence of nicotine, carbon monoxide, hydrogen cyanide, cadmium and various other aromatic hydrocarbons, but the two most dangerous chemicals that are found in cigarettes are nicotine and carbon monoxide. Nicotine causes the babies heart rate to speed up, reduces placental vascularisation, constricts the placental arteries, and thickens the endothelium of placental blood vessels. This creates a reduction in the placental blood flow, and further reductions in oxygen delivery. As well nicotine interferes with the ability of the placenta to feed the baby the nutrients it requires. Therefore the babies growth is slowed down. Carbon monoxide causes growing cells to be starved of oxygen, and effects the brain. This can lead to a low birth weight and higher chance of the baby dying at birth. Smoking is the single largest modifiable( ch angeable) risk factor in fetal growth retardation. Maternal smoking during pregnancy is also associated with genetic defects as well as an increased incidence of congenital malformations such as cleft palates, microcephalus, and clubfoot. Mothers who smoke one pack a day during pregnancy have an 85% increased risk of having a child with mental retardation. Mothers that smoke during their pregnancy have double the chance of having a child with behavural problems. Another one of the biggest factors that disrupts fetal growth and development is alcohol. This is a very common substance abuse of pregnant women. Everytime the pregnant mother is drinking, her fetus is also drinking. The alcohol crosses the placental barrier, and goes directly into the fetus's liver. The ethanol found in alcohol may impair the nutrient support of the fetus. Acetaldehyde, a major metabolite, crosses the placenta and is teratogenic. Since the alcohol stays in the fetus for a long time, the small liver is unable to metabolize the alcohol. The alcohol also travels through the blood stream going directly to the baby's brain, and this can damage the central nervous system. The common, severe, and hazardous side effect that happens to the fetus because of alcohol is Fetal Alcohol Syndrome. This is a very serious side effect that has lasting and sometimes ... ...e the death of the fetus. Pregnant women should distant themselves from heavy metals. such as, lead and methyl mercury which can harm the fetus. All pregnant women should be aware and cautious about contacting a disease. Some of the diseases are fatal and very hazardous to the fetus, while some only have minor effects on the fetus. Many of the diseases contacted by pregnant mothers are sexually contacted diseases. Some examples of these diseases are Aids, and Gonorrhea. There are also other non-related diseases such as, Rubella, and Toxoplasmolisis and, which can affect the fetus.   Ã‚  Ã‚  Ã‚  Ã‚  Toxoplasmolisis is a bacterial infection. This is a parasitic disease that can effect the fetus, by causing growth retardation. Another harmful disease that can affect the fetus is Rubella or otherwise called German Measles. Pregnant woman that have Rubella during the first trimester can effect the fetus and cause a syndrome of birth defects called congenital rubella syndrome. This can cause deafness, cataracts, congenital heart disease, and mental retardation. In conclusion, pregnant women should try to avoid all substances that can be potentially harmful to the fetus within them.

Psychosocial Treatments For Premature Ejaculation Health And Social Care Essay

Premature interjection ( PE ) is a really common sexual disfunction among patients and changing prevalence estimations runing from 20 % down to 3 % . Premature interjection is characterized by interjection [ that ] ever or about ever occurs anterior to or within about 1 min of vaginal incursion ; inability to detain interjection on all or about all vaginal incursions ; and negative personal effects, such as hurt, bother, defeat and/or the turning away of sexual familiarity. Although psychological issues are present in most of the patients with premature PE, as a cause or as a effect, research on the effects of psychological attacks for PE has in general non been controlled or randomised and is missing in long-run followup.Aims ATo measure the efficaciousness of psychosocial intercessions for PE. To look into any differences in efficaciousness between different types of psychosocial interventions for PE. To compare psychosocial intercessions with pharmacological intervention and pharmacological intervention in association with psychosocial intervention for PE.Search methods ATests were searched in computerized general and specialised databases, such as: Medline by Pubmed ( 1966 to 2010 ) ; PsycINFO ( 1974 to 2010 ) ; EMBASE ( 1980 to 2010 ) ; LILACS ( 1982 to 2010 ) ; Cochrane Central Register of Controlled Trials ( Cochrane Library, 2010 ) ; and by look intoing bibliographies, and reaching makers and research workers.Choice standards ATests were eligible if they were Rrandomised or quasi-randomised controlled tests measuring psychosocial intercessions for PE. Surveies compared ingwith different psychosocial intercessions, pharmacological intercessions, waiting list, or no intervention for PE.Data aggregation and analysis AInformation on patients, intercessions, and results was extracted by at least two independent referees utilizing a standard signifier. The primary result step for comparing the effects of psychosocial intercessions to waiting list and standard medicines was betterment in IELT ( i.e. , clip from vaginal incursion to interjection ) . The secondary result was alteration in validated PE questionnaires.Consequences AOne survey ( De Carufel 2006 ) showed important betterments in continuance of intercourse ( MD:407.90 ; CI:302.42, 513.38 ) twosomes ‘ sexual satisfaction ( MD: -26.10 ; CI: -50.48, -1.72 ) and sexual map in favor of behavioural therapy ( BT ) compared with waiting list. This survey besides showed that a new Functional-sexological intervention ( FS ) was significantly better than waiting list for continuance of intercourse ( MD:412.00 ; CI:305.88- 518.12 ) , alteration over clip in subjective perceptual experience of continuance of intercourse ( Womans: MD:2.88 ; CI: 2.06, 3.70 ; Work force: MD:2.52 ; CI:1.65, 3.39 ) and twosomes ‘ sexual satisfaction ( MD -25.10 CI [ -47.95, -2.25 ) . One survey ( Li 2006 ) showed that the combination of Thorazine and BT was superior than chlorpromazine entirely related to the IELT ( MD:1.11 ; CI:0.82, 1.40 ) , SAS ( MD: -8.72 ; CI: -11.09, -6.35 ) and to some CIPE inquiries ( anxiousness in sexual activity, spouse sexual satisfaction, patient sexual satisfaction, control ejaculatory physiological reaction and ejaculatory latency ) . One survey ( Yuan 2008 ) showed that the direct comparing between BT and citalopram showed important difference in betterment of IELT ( Risk Ratio:0.52 ; CI:0.34, 0.78 ) and in the figure of twosomes satisfied with sex life after the intervention ( Risk Ratio: 0.60 ; CI:0.39, 0.93 ) in favor to drug therapy.Writers ‘ decisions AOverall, weak grounds shows that psychological intercessions are effectual in the intervention of PE. RandomisedA , controlled surveies of psychotherapeutics for PE are few, and the bulk has a little sample size. The early success studies ( 97,8 % ) of Masters and Johnson could non be replicated. One survey found a important betterment from baseline in the continuance of intercourse, sexual satisfaction and sexual map with new functional-sexological intervention and behaviour therapy compared to waiting list. One survey showed that the combination of Thorazine and BT was superior than Thorazine entirely. Randomised tests with larger group samples tests a re still needed to further research the current available grounds for psychological intercessions for handling PE.Plain linguistic communication sum-up APsychosocial intercessions for premature interjectionAPremature interjection ( PE ) is a really common ailment among work forces. Is characterized by interjection which ever or about ever occurs anterior to or within about one minute of vaginal incursion ; and inability to detain interjection on all or about all vaginal incursions ; and negative personal effects, such as hurt, bother, defeat and/or the turning away of sexual familiarity. Although psychological issues are present in most of the patients with PE, as a cause or as a effect, research on the effects of psychological attacks for PE is non clear. The early success studies ( 97.8 % ) of Masters and Johnson could non be replicated.This reappraisal assessed the efficaciousness of psychosocial intercessions for PE and found four tests that affecting 253 PE patients. Weak groun ds shows that psychological intercessions alone/or in combination with medicine are effectual in the intervention of PE.ABackground ADescription of the status APremature interjection is a really common sexual disfunction among patients and changing prevalence estimations runing from 20 % down to 3 % ( Simons 2001 ; Porst 2007 ; Jannini 2005 ; Althof 2010 ) . The prevalence rate depend on what definition were considered ( Althof 2010 ) . PE A is a ego defined status and there is no established diagnostic trial for this status, but at that place have A been many different definitions of PE ( Melnik 2009a ) . These definitions have been imprecise, subjective and missing an grounds base doing confusion as to what truly constitutes PE Intravaginal ejaculatory latency clip ( IELT ) is an nonsubjective ( timed ) step of the Until clip from vaginal incursion until interjection. It is one of the standard primary result steps in clinical tests of PE. Standards have been published that define any interjection happening in 1 min, 2 min, 3 min or even 7 min from incursion, or 8-15 penile pushs, as premature.A Alternatively, the European Association of Urology upsets of interjection guidelines, published in 2004, defined PE as the inability to command interjection for a â€Å" sufficient † length of clip before vaginal incursion ( McMahon 2008a ) . A population-based multicenter survey with 500 twosomes from five states: the Netherlands, United Kingdom, Spain, Turkey, and the United States utilizing a stop-watch during intercourse showed a average IELT of 5.4 proceedingss ( 0.55-44.1 proceedingss ) . This multicenter survey was conducted on a â€Å" normal † general male population, with no complains of PE ( Waldinger 2009 ) . Recently, the International Society for Sexual Medicine has proposed the following evidence-based definition: â€Å" Premature interjection is a male sexual disfunction characterized by interjection [ that ] ever or about ever occurs anterior to or within about 1 min of vaginal incursion ; inability to detain interjection on all or about all vaginal incursions ; and negative personal effects, such as hurt, bother, defeat and/or the turning away of sexual familiarity † ( McMahon 2008a ) . Subtypes of PE are defined harmonizing to their features and include womb-to-tomb versus acquired PE, planetary ( it occurs in all sexual brushs ) versus situational PE ( it happens in some state of affairss, with some spouses ) , and subtypes based on the accompaniment of other sexual jobs, peculiarly erectile disfunction ( Waldinger 2006a ; Waldinger 2006b ; APA 2000 ) . Time to blurt out is of import, but PE entirely based on IELT does non accurately qualify the status. PE is a multidimensional status and IELT entirely is non sufficient to qualify it. Other of import facets to include in the diagnosing include the patient ‘s subjective feeling of deficiency of control and the negative psychosocial effects of the status ( hurt ) A ( Jannini 2005 ; Porst 2007 ) , PE has a important consequence on the wellbeing of persons and on their sexual relationships ( McCabe 1970 ; Dunn 1999 ) . Work force with PE have reported reduced sexual assurance, trouble in set uping relationships and hurt at non fulfilling their spouses because of PE ( McMahon 2004, McMahon 2008b ; McMahon 2008c ; Symonds 2003 ; Rowland 2007 ; Patrick 2005 ) .Description of the intercession ACurrent schemes for PE therapy arise from both pharmacologic and psychological positions, reflecting restrictions in comprehension of the etiology of PE ( Melnik 2009a ) . The determiners of PE are doubtless complex, with differences between work forces with A A womb-to-tomb PE from work forces with acquired PE. Biogenic theories of PE have been multivariate at best, runing from psychosomatic manifestations of anxiousness or forming from early sexual experience to biologic accounts such as a hyperexcitable ejaculatory physiological reaction or disfunction of 5-hydroxytryptamine ( 5-HT ) receptor Waldinger 2008. Indeed, SSRIs, which modulate 5-HT signaling, have demonstrated efficaciousness in this scene and may be prescribed off-label to work forces with PE. Whether pharmacological agents such as dapoxetine or off-label clomipramine ( a TCA ) , paroxetine, Zoloft, and Prozac, or with day-to-day dosing of off-label paroxetine, clomipramine, Zoloft, Prozac, or citalopram should be encouraged as a first line intervention intercession ( Althof 2010 ) these medicines are a simple and, if non used for a life-time, cost effectual intervention for PE, there are some restrictions to their widespread usage. First, supplying a systemic drug for PE may be unneeded, given reasonably good results from psychosocial intercessions. Second, the serotonergic drugs have been associated with lessened desire, and in some instances, diminished rousing. Therefore, these drugs would non be recommended for patients who besides have low sexual desire or erectile disfunction. Third, they would non be recommended for patients with an undiagnosed bipolar upset, as they may significantly increase the likeliness of oncoming of a frenzied episode. Finally, are besides m inor side effects that accompany any drug usage, and these should be examined in footings of patient tolerance. Although psychological issues are present in most of the patients with PE, as a cause or as a effect, research on the effects of psychological attacks for PE is non clear The first publications on psychotherapeutics result surveies emphasized the psychological facets in the etiology of PE ( Althof 2007 ; Althof 2006 ; Kaplan 1974 ; Kaplan 1989 ) . The most normally proposed theories on the causality of PE, attribute it to a †conditioned physiological reaction † by which a form of speedy interjection is thought to go habituated. When onanism or sexual intercourse is repeatedly hurried, because of fright of find, anxiousness or guilt, †a rapid response may follow † . Based on this belief, in 1956, the urologist James Semans published behavioural intercessions for the direction of PE the â€Å" stop-start † technique ( Semans 1956 ) . Semans reported that 100 % of his patients utilizing the â€Å" stop-and-start † technique succeeded in commanding the minute of interjection. This method involves the spouse exciting the adult male ‘s phallus until he has the esthesis of about climaxing, at which clip stimulation is ceased until this feeling abates. The sequence may be repeated until the interjection can be controlled voluntarily ( Semans 1956 ) . With the grounds presently available, there are no informations back uping and retroflexing the old consequences reached by Semans, or even consensus account why this government may work. In the 1970ss, Masters and Johnson ( Masters 1970 ) , reported that after traveling through a two-week plan, 97.8 % of their clients presented remittal of PE. The â€Å" squeezing technique † proposed by them involves single and twosomes therapy, and requires the female spouse to squash the frenulum of the phallus for a few seconds one time the male has achieved â€Å" full hard-on † and begins to feel the impulse to blurt out. After the squeezing is released, a twosome must wait for approximately 30 seconds. This direction is followed until the male has delayed blurt outing for a period of 1520A proceedingss. Once the male learns to detain interjection, insertion ( and finally intercourse ) can be attempted utilizing the female superior place and she is instructed non to travel. The eventual end is for the male to develop sufficient control over his interjection to protract vaginal intercourse. The reported failure rates of 2.2 % instantly after intervention and 2.7 % at the five twelvemonth followup. Other research workers have been unable to retroflex Masters and Johnson ‘s success rates. Numerous minor changes to these two BASICs techniques have been suggested over the old ages by other sex research workers. Reccently the International Society for Sexual Medicine ( ISSM ) defines four chief psychotherapeutic intervention groups. These include: behavior therapy, particularly modified Masters and Johnson and Semans techniques, psycho instruction, psychodynamic therapy and cognitive behavioral therapy ( CBT ) ( Althof 2010 ) . The more normally examined psychotherapeuticss are derived from cognitive behavioral schools. These therapies are developed from cognitive therapy, which focuses on dysfunctional beliefs, and so incorporates constituents of behavioural psychotherapeutics, and its purpose is to rectify the negative deformed knowledges and dysfunctional underlying beliefs that maintain sexual disfunction. They include cognitive therapies, behavioral therapies, job work outing therapies and curative reading stuffs ( bibliotherapy ) . Numerous descriptive surveies hav e examined the proficient issues in accommodating these therapies to the clinical diverseness. Some of the more of import versions include stressing A behavioral techniques, peculiarly earlier in therapy and frequently reiterating information, utilizing different centripetal modes.How the intercession might work ASexually outcomes surveies must entree the complex interplay between the biological, emotional, psychological and relational constituents of persons and twosomes lives. Besides PE has been associated with anxiousness, depression, and hurt in work forces and their female spouses. Phamarcological intercession entrees portion of this complex â€Å" scenario † . Psychotherapy intercessions aims to alter dysfunctional feelings and attitudes and aid persons to develop to healthier, more effectual forms of behaviour. Harmonizing Althof 2002 A one of the lessons learned from the †Viagra revolution was that no affair how efficacious and safe the medical intercession, me dicines entirely could non ever overcome the psychosocial obstructions that maintained the disfunction and interfered with sexual life â€Å" . The premise behind psychosocial intercessions is that when patients learn about PE they begin to develop new sexual direction schemes to cover with restrictive sexual forms ; turning away of sexual activity ; and an involuntariness to discourse sex with a spouse ( Metz 1997 ) . The proposal is to: supply an empathic, supportive clinician-patient relationship, cut down or extinguish public presentation anxiousness, and assist him derive or recover sexual assurance ; alteration opposition to medical therapy, every bit good as to supervise topics ‘ clinical position and intervention response ; and modify his maladaptive sexual â€Å" books † ( Some signifiers of cognitive deformations ( e.g. generalisation of the sexual trouble, self observation during the sexual activity ) may interfere with sexual map. These issues need to be addressed during the psychotherapeutics procedure ( Althof 2006 ; Colpi 2004 ) . Some signifiers of cognitive deformation may interfere with sexual map that why is of import to supply didactic information and cut down the stigma associated with the premature interjection ( Althof 2006 ; Althof 2007 ) .Why it is of import to make this reappraisal AWork force with PE A study decreased sexual assurance, trouble in set uping relationships, and a negative impact on their quality of life. The consequence of PE on the person and the sexual relationship is important. On the other manus, the drug intervention offers benefits, but besides of import inauspicious effects which can impact its prescription A usage. So, a systematic reappraisal measuring the effects of psychological intercessions for PE seems seasonably.Aims ATo measure the efficaciousness of psychosocial interventions are effectual in the intervention of premature interjection. To look into if there are differences in efficaciousness between the different types of psychosocial intervention in PE. To compare psychosocial intercessions with pharmacological intervention and pharmacological intervention in association with psychosocial intervention on bettering on PE. To execute a meta-analytic synthesis of surveies, when possible.Methods AStandards for sing surveies for this reappraisal ATypes of surveies AAll published or unpublished randomised and quasi-randomised controlled tests measuring psychosocial intercessions for PE. Studies comparing psychosocial intercessions versus either pharmacological intercession or waiting list or no intercession or with another psychosocial intercession were eligible for this reappraisal.Types of participants APatients were included in this reappraisal if diagnosed with premature interjection, either defined by trialists harmonizing to DSM III ; IV ; IV-R, ICD or International Consensus standards. When tests failed to use diagnostic standards, the badness of PE was described by the usage of standardised evaluation graduated tables.Types of intercessions AExperimental intercessionsAny psychosocial intercessions that was A validated or described by the survey ‘s writer as being for premature interjection in tervention, as for illustration behaviour therapy, particularly modified Masters and Johnson and Semans techniques and psycho-education. Combined psychosocial intercessions were besides included in this reappraisal. In order to be eligible, a survey should include at least one group where merely some psychosocial intercession was given.Control InterventionsOther psychosocial intervention, placebo, non-intervention, pharmacological intervention and pharmacological intervention in association with psychosocial intervention.Types of result steps APrimary results AImprovement in IELT ( i.e. , clip from vaginal incursion to interjection, interjection latent clip ) ( McMahon 2008a ) Patient studies of betterment in control over interjection ( McMahon 2008a ) Patient ( and/or spouse ) studies of betterment in satisfaction with sexual intercourse ( McMahon 2008a )Secondary results AWhere informations were available, secondary results included: Chinese Index Premature Ejaculation ( CIPE ) – ego administered ( Yuan 2004 ) ; Change over clip in sexual satisfaction ( work forces and spouse are individually evaluated ) ; Sexual Interaction Inventory ( SII ) ( Hudson 1982 ) ; Satisfaction with Treatment Althof 2010 ; Self-rating Anxiety Scale ( SAS ) ( Zung 1971 ) ; Change over Time in Subjective Perception of Duration of Intercourse ( Scale 1 to 9 ) ; Change over Time in Objective Measure of Duration of Intercourse from Penetration to Ejaculation ( in Seconds ) .Search methods for designation of surveies A( ( â€Å" Ejaculation † [ Mesh ] ) or ( premature interjection ) or ( rapid interjection ) or ( ejaculatory upsets general pattern ) ( psychotherap* ) OR ( psychosocial intercession ) OR ( psychoeducation ) OR ( get bying accomplishments ) OR ( brief motivational guidance ) OR ( sexual therapy ) OR ( anxiety direction preparation ) OR ( matrimonial therapy ) OR ( group therapy ) OR ( cognitive therapy ) OR ( behavio* therapy ) OR ( focal therapy* ) OR ( general guidance ) OR ( psychodynamic therapy ) OR ( supportive therapy ) OR ( psychoanalyses ) OR ( interpersonal therapy ) OR ( cognitive therapy ) OR ( single therapy ) OR ( twosomes therapy ) OR ( waiting list ) ) ( â€Å" Counseling † [ Mesh ] ) or ( reding ) or ( Counselors ) or ( Counselor ) # 2 OR # 3 ( ( randomised controlled test [ platinum ] ) or ( controlled clinical test [ platinum ] ) or ( randomised [ tiab ] ) or ( placebo [ tiab ] ) or ( drug therapy [ sh ] ) or ( randomly [ tiab ] ) or ( test [ tiab ] ) or ( groups [ tiab ] ) ) non ( animate beings [ mh ] non ( worlds [ mh ] and animate beings [ mh ] ) ) # 1 AND # 4 AND # 5Electronic hunts A We searched the undermentioned databases: MEDLINE by Pubmed ( 1966 to 2009 ) ; PsycINFO ( 1974 to 2010 ) ; EMBASE ( 1980 to 2010 ) ; LILACS ( 1982 to 2010 ) ; Cochrane Central Register of Controlled Trials ( Cochrane Library, 2010 ) .Electronic hunts AWe searched the undermentioned databases: MEDLINE by Pubmed ( 1966 to 2009 ) ; PsycINFO ( 1974 to 2010 ) ; EMBASE ( 1980 to 2010 ) ; LILACS ( 1982 to 2010 ) ; Cochrane Central Register of Controlled Trials ( Cochrane Library, 2010 ) .Searching other resources ADesignation of all surveies via experts in the field, conference proceeding and personal communications. Handseaching of mentions notes of included surveies and relevant reappraisals. Unpublished studies, abstract and studies were considered for inclusion on the same footing as published studies. There were no limitations based on linguistic communication or day of the month. Handseaching the first publications of Archivess of Sexual Behavior, Journal of Sex & A ; Marital Therapy, and Journal of Sexual MedicineData aggregation and analysis AChoice of surveies ATwo referees ( TM and RR ) independently assessed ( blind to the determination made by each other ) the relevancy of each abstract produced by the hunt scheme. These were categorized into Relevant, Not relevant and Unsure. Articles of all relevant and diffident commendations were retrieved. Citations were read by each reappraisal writer ( blind to the determination made by each other ) utilizing pre-set standards and a entering sheet to place those included in the reappraisal. In instances of dissension, unfastened treatment took topographic point between all reappraisal writers and a determination was reached by consensus. Reasons for inclusion and exclusion were recorded.Data extraction and direction ADatas were being extracted from tests that met the inclusion standards. Data A included: inclusio n/exclusion standards ; method of randomization ; allotment privacy ; judge ‘s sightlessness ; sample size ; intention-to-treat Numberss ; figure and grounds for drop-outs ; age ; wellness position ; enlisting beginning ; initial tonss and standard divergence of all evaluation graduated tables applied ( including QoL ) ; diagnosing standards used ; length of test ; follow-up period ; length and frequence of Sessionss ; puting of therapy ; therapy type and theoretical account used ( i.e group or single therapy ) . For primary and secondary results, end point tonss and standard divergences from all evaluation graduated tables were extracted. In tests utilizing pharmacotherapy, the name of medicine, dose, frequence, side effects, and conformity were recorded. When informations were ill-defined or losing, matching writer was contacted.Appraisal of hazard of prejudice in included surveies AQuality appraisalThe methodological quality of the included tests in conformity to the Cochra ne Handbook for Systematic Reviews of Interventions ( Higgins 2008 ) . The ratings were compared and any incompatibilities between the reappraisal writers in the reading of inclusion standards and their significance to the selected tests were discussed and resolved. The undermentioned spheres were assessed as ‘Yes ‘ ( i.e. low hazard of prejudice ) , ‘Unclear ‘ ( unsure hazard of prejudice ) or ‘No ‘ ( i.e. high hazard of prejudice ) . The survey writer ( s ) were contacted to seek elucidation in instance of uncertainness over informations: Was the sequence coevals adequate? Was allotment adequately concealed? Was cognition of the allocated intercessions adequately prevented during the survey? Were uncomplete result informations adequately addressed? Are studies of the survey free of suggestion of selective result coverage? Was the survey seemingly free of other jobs that could set it at a high hazard of prejudice? These appraisals were reported for each person survey in the ‘Risk of prejudice in included surveies ‘ tabular array under the ‘Characteristics of included surveies ‘ , and jointly here: ‘Figure 30 ‘ , ‘Figure 31 ‘ .Measures of intervention consequence AFor uninterrupted informations, such as CIPE ( Chinese Index of Premature Ejaculation ) , the chief results of involvement was the alteration in mark from baseline to concluding appraisal. We used average difference ( MD ) with 95 % assurance interval ( CI ) . For dichotomous results, such as patient studies of betterment in control over interjection, the end point is of involvement, and the hazard ratio ( RR ) with 95 % CI were used to mensurate intervention consequence.Unit of measurement of analysis issues AFor tests comparing more than two intercession groups, the relevant intercession group was assessed. Couple, spouse and the patients themselves were besides considered.Covering with losing informations AFor dichotomous results, all exclusions/dropouts were identified. If no information available ( either from the study or the writers ) , it was assumed that dropout was due to intervention failure in conformity with ITT rules. The sensitiveness of the consequences to this premise were tested. For surveies utilizing uninterrupted results in which standard divergence ( SD ) was non reported, and no information was available from the survey writers, an SD was impute through obtaining the mean SD across surveies for intervention and control groups.Appraisal of heterogeneousness AStatistical heterogeneousness in the consequences of the tests was assessed diagrammatically and by the I2 statistic. An I2 of a†°? 50 % was considered considerable heterogeneousness, and we used the random-effects theoretical account. If I2 is & lt ; 50 % , we used a fixed-effect theoretical account. Possible grounds for clinical heterogeneousness were: 1.A A A the type of intercession offered ( single, twosome or group mode ) ; 2.A A A the badness of symptoms at baseline ( harmonizing with ego administered PE questionnaires ) ; 3.A A A the figure of psychological therapy Sessionss offered ; 4.A A A the proportion of participants being on medicine. Possible beginnings of heterogeneousness were assessed by sensitiveness and subgroup analyses as described above ( Higgins 2008 ) . Clinical heterogeneousness was explored by looking at separate subgroups of tests.Appraisal of describing prejudices AWe attempted to cut down publication and related prejudice ( PRB ) through the usage of alternate, robust hunt schemes, including handsearching Archivess of Sexual Behavior, Journal of Sex & A ; Marital Therapy, and Journal of Sexual Medicine. We were besides make usage of Internet hunt engines, conduct a comprehensive hunt of the gray literature, alternate beginnings of informations or synthesized grounds, A and contact experts in sexology research. Possible beginnings of coverage prejudices, which could be as publication prejudice, linguistic communication prejudice, commendation prejudice, hapless methodological quality, and heterogeneousness, and were analysed harmonizing to the surveies in inquiry.Data synthesis ADue to the intercessions and results heterogeneousness, it was non possible to pool the informations and to execute a meta-analysis.Dichotomous and uninterrupted informationsDichotomous results were pooled utilizing comparative hazards. For uninterrupted results, two methods will be used for pooling informations. Where all tests measured an result utilizing the same graduated tables and where the mean, standard divergence and sample size in each group were known, average differences ( MD ) were calculated. Where some of the tests measured results on different graduated tables and it will non see appropriate to straight unite informations from these steps, the standardized mean difference ( SMD ) was calculated. Both dichotomous and uninterrupted results were presented with 95 % assurance intervals.Subgroup analysis and probe of heterogeneousness AInitially was planned to execute subgroup analysis for subsets of participants ( such as individual versus holding a relationship ; immature versus aged ) , badness of PE ( mild, moderate, terrible ) , different psychotherapeutics technique ( single, twosome or group mode ) , figure of psychological therapy Sessionss offered, or drop-outs to research clinical heterogeneousness in the meta-analysis. Due to the little figure of included surveies and deficiency of available information sing these variables, merely different psychotherapeutics technique was considered for subgroup analysis.Sensitivity analysis ADue to the intercessions and results heterogeneousness, it was non possible to pool the informations and to execute sensitiveness analyses.Consequences ADescription of surveies ASee ‘Characteristics of included surveies ‘ , ‘Chara cteristics of excluded surveies ‘ .Consequences of the hunt AThe electronic and manual hunts resulted in 504 mentions, of which 487 were clearly non relevant to this reappraisal. Of the staying 17 mentions, 13 were excluded after reading the full documents.Included surveies AFour surveies affecting 253 PE patients met the inclusion standards and three of them were non-English surveies. There was full understanding on the inclusion of the five surveies for the reappraisal. Duration of included tests covered two hebdomads to twelve hebdomads. These tests included 253 male participants and 36 twosomes. Three tests compared psychotherapeutics techniques for PE versus pharmacological intercession and one compared the psychotherapeutics either with waiting list or functional-sexological intervention. These surveies were used to turn to the three aims outlined in the debut to this reappraisal.PutingAll surveies were conducted on an outpatient footing and were carried out in Canada ( n = 1 ) , China ( n = 2 ) and Egypt ( n = 1 ) .ParticipantsThe participants were consistent with the DSM-IV or DSM-III R diagnosing of PE and by the International Society of Sexual Medicine PE Criteria ( McMahon 2008 ) .InterventionsThe first aim was to find whether psychosocial interventions are effectual in handling PE and for this proposal merely one test was included. De Carufel 2006 evaluated the effects of a new functional-sexological ( FS ) intervention for PE. The intervention is intended to better control over the minute of interjection ; work forces larn how to command their rousing without holding to disrupt sexual activity. This intervention is based on the transition of sexual exhilaration through simple techniques: work forces are instructed to concentrate on the temporal, spacial and energetic dimensions of their motions, to utilize their musculuss in different ways ( for illustration, to loosen up the natess ) , to change theA velocity of sexual activity before and during intercourse, to take a breath from the stop, and to utilize places that require less muscular tenseness ( De Carufel 2006 ) . Treatment besides includes instruction on sensualness and information about the sexual responses of work forces and adult females. Study participants met the undermentioned choice standards: the adult male ‘s IELT was A less than two proc eedingss ; the twosome ‘s relationship was ongoing for at least one twelvemonth ; participants agreed to either take portion in hebdomadal meetings as a twosome or undergo a 12-week waiting list followed by a matrimonial intercession for the intervention of PE ; and participants presented with no major mental or physiological wellness jobs. Thirty-six A twosomes received one of three curative options: the new functional-sexological ( FS ) intervention ; a behavioural intervention ( BT ) including the squeezing and stop-start techniques ; or a 12-week waiting list ( WL ) . Participants provided an nonsubjective step of the continuance of intercourse from incursion to interjection. IELT was assessed prior to intervention, A during intervention and at follow-up. The consequences indicated that the FS intervention was really effectual and led to important betterments in the continuance of intercourse ( Figure 1 ) , sexual satisfaction ( Figure 18, Figure 19, Figure 21, Figure 24, Figure 27 ) and sexual map compared with the WL group. This comparing showed no difference sing the other results ( Figure 6, Figure 16, Figure 17, Figure 20, Figure 21, Figure 25, Figure 27, Figure 26 ) . The behavioural intervention obtained similar consequences compared with the FS therapy sing all results assessed ( Figure 8, Figure 9, Figure 10, Figure 7, Figure 12 ) . The comparing between BT versus WL showed better consequences in favor to BT group sing the undermentioned results: a ) continuance of intercourse from incursion to interjection ( Figure 1 ) ; B ) alteration over clip in subjective perceptual experience of continuance of intercourse ( Figure 14, Figure 15 ) ; c ) frequence of satisfaction for adult females ( Figure 23, analysis 5.7.1 ) ; vitamin D ) perceived pleasance for adult females ( Figure 23, analysis 5.7.4 ) ; vitamin E ) twosome ‘s sexual satisfaction ( Figure 24 ) .There was no difference between these intercessions sing sexual Interaction Invento ry Over Time – Work force ( Analysis 5.1 ) . The 2nd aim was to look into if efficacy differs between the different types of psychosocial intervention for PE. For this proposal, the merely included survey was the De Carrufel test which was described supra. This survey compared BT versus functional-sexological intervention. The 3rd aim was to compare the psychotherapeutics with the pharmacotherapy in patients with PE and three surveies fulfilled this demand: : Yuan 2008 indiscriminately allocated 96 patients with PE to one of three groups: behavioural therapy merely ( n = 32 ) ; citalopram ( a selective 5-hydroxytryptamine reuptake inhibitor ) merely ( n = 32 ) ; and a combination of citalopram and behavioural therapy ( n = 32 ) . The result steps were self reported IELT and both spouses satisfaction with their sexual life ( Yuan 2008 ) . After intercession, all three groups showed a important addition in the clip oversight before interjection. The direct comparing between citalopram-only versus BT-only favoured the citalopram group for the IELT ( Figure 5 ) and spouses sexual satisfaction ( Figure 28 ) .The comparing between combined attack versus citalopram-only favoured the combination group for both results ( .Figure 11, Figure 29 ) . The combined-approach group reported the highest sexual satisfaction, followed by the citalopram-only and behavioral-therapy-only groups. The writers concluded that the combined attack was an effectual in tervention for PE. In this survey, for statistical analysis, the conditions â€Å" satisfied † and â€Å" fundamentally satisfied † were classified as a alone group, therefore were non individually evaluated sing the result sexual satisfaction with sex life ( both spouses together ) . Fifty-one 2006 indiscriminately allocated 90 patients with PE to one of two groups: psychological intercession plus Thorazine ( n = 45 ) ; and chlorpromazine merely ( control group ; n = 45 ) . Chlorpromazine ( tri-cyclic antidepressant ) intervention comprised unwritten tablets ( 25 milligram ) taken twice daily for a sum of 6 hebdomads ; the intercession group besides received comprehensive behavioural psychotherapeutics. Each session of psychological intervention lasted at least 30 min, and Sessionss were given twice per hebdomad during this period. The result steps were tonss on the Chinese Index of Sexual Function for PE ( CIPE ) and IELT. CIPE scores for control of ejaculatory physiological reaction, sexual satisfaction of the patients and their spouses and anxiousness or depression about sexual activity were significantly better in the combined-intervention group than in the control group ( Figure 3 ) . The results IELT and SAS graduated table besides favoured the combined att ack ( Figure 2, Figure 4 ) . At follow-up, one month after intervention, the efficaciousness rates ( as IELT ) of the two groups were 82.9 % and 30 % , severally ( P & lt ; 0.01 ) ( Figure 13 ) . The writers concluded that a behavioural psychotherapeutics intercession enhanced the clinical efficaciousness of drug intervention for PE ( Melnik 2009 ) . Abdel-Hamid 2001 conducted a prospective, double-blind, randomised, crossing over survey of 31 patients with primary PE. Patients received one of four drugs administered on an as-needed footing 35 hours before awaited sexual intercourse ( clomipramine, Zoloft, paroxetine, Viagra ) or were instructed to utilize the pause-squeeze technique. The survey consisted of five 4-week periods of intervention, separated by 2-week washout periods. Anxiety mark and interjection latency clip were measured before intervention, after each intervention and during washout periods. Sexual satisfaction tonss were measured after each intervention. The three antidepressants ( clomipramine, Zoloft and paroxetine ) were tantamount in footings of efficaciousness and safety ( Abdel-Hamid 2001 ) . The pause-squeeze technique was associated with the lowest success rate ( 54.8 % ) compared with other modes. In add-on, the technique was associated with lower sexual satisfaction tonss and lower ejaculatory latency times in comparing with those achieved with Viagra and paroxetine, but the values were comparable to those achieved with clomipramine and Zoloft. For these patients with PE, Viagra showed the best consequences in footings of ejaculatory latency and satisfaction. This survey demonstrates besides that paroxetine is superior to the pause-squeeze technique in footings of ejaculatory latency and sexual satisfaction. It was non possible to pull out informations of this survey since the mean and standard divergence were non presented, merely the median. Besides that, the first writer declared that these informations were non available any longer. The 4th aim was determine whether psychosocial interventions were effectual for PE compared with drug therapy and for this, there were two surveies: Yuan 2008 and Abdel-Hamid 2001, which were described above.ResultsRating graduated tables included in this reappraisal: The Chinese Index of Premature Ejaculation ( CIPE ) is frequently used as a diagnostic tool.A It has five points that assess interjection clip from insertion, control of over IELT times, sexual satisfaction, spouse satisfaction and anxiousness and depression related to sex. Improvement in Ejaculation Latency Time ( IELT ) Patient studies of betterment in control over interjection ( McMahon 2008a ) Patient ( and/or spouse ) studies of betterment in satisfaction with sexual intercourse Change over Time in Subjective Perception of Duration of Intercourse Change over Time in Sexual Satisfaction Sexual Interaction Inventory over Time Satisfaction with Treatment Change over Time in Subjective Perception of Duration of Intercourse ( Scale of 1 to 9 ) Change over Time in Objective Measure of Duration of Intercourse from Penetration to Ejaculation ( in seconds )Excluded surveies ATwelve clinical tests were excluded ( despite being about intercessions for people with PE ) because they did non incorporate a control group. The surveies and the grounds for exclusions are presented in the ‘Characteristics of excluded surveies ‘ . Expecting appraisal There are no surveies expecting appraisal. Ongoing surveies We know of no on-going surveies.Hazard of prejudice in included surveies ADe Carufel 2006 and Abdel-Hamid 2001 were categorized as low hazard of prejudice. Fifty-one 2006 and Yuan 2008 were categorized as moderate hazard of prejudice. Of the four surveies included, all specified the method of randomization ( De Carufel 2006 ; Abdel-Hamid 2001 ; Yuan 2008 ; Li 2006 ) ( ‘Figure 31 ‘ ) .Allocation AAllotment was adequately concealed in two included tests ( Abdel-Hamid 2001 ; De Carufel 2006 ) and ill-defined in the other two ( Fifty-one 2006 ; Yuan 2008 ) ( ‘Figure 30 ‘ ) .Blinding APatient ‘s blinding was non considered applicable for psychosocial intercessions surveies. Consequently, the writers considered merely the judges blinding. Evaluator ‘s blinding was mentioned in merely two included tests ( Abdel-Hamid 2001 ; De Carufel 2006 ) ( ‘Figure 30 ‘ ) .Incomplete result informations AMerely one survey did no reference result information s ( Abdel-Hamid 2001 ) ( ‘Figure 30 ‘ ) .Selective coverage AMerely Li 2006 survey was considered free of selective coverage ( ‘Figure 30 ‘ ) .Other possible beginnings of prejudice AMerely Abdel-Hamid 2001 survey was considered free of other prejudice ( ‘Figure 30 ‘ ) .Effectss of intercessions AEffectss of intercessions are described in the Heading â€Å" Included Studies † , under the subheading ‘Interventions ‘ ( ‘Included surveies ‘ ) .Discussion ASummary of chief consequences AOne survey ( De Carufel 2006 ) showed important betterment in continuance of intercourse, twosomes ‘ sexual satisfaction and sexual map in favor of BT and a new Functional-sexological intervention ; compared with waiting list. One survey ( Li 2006 ) showed that the combination of Thorazine and BT was superior than chlorpromazine entirely related to the IELT, SAS and to CIPE. On survey ( Yuan 2008 ) showed that the direct comparing between BT and citalopram showed important difference in betterment of IELT in favor to drug therapy. The consequences of reviewed tests yield inconsistent and hapless decisions sing the effectivity of psychotherapeutics.Overall completeness and pertinence of grounds AIndeed, this was the first systematic reappraisals about psychosocial intercessions for PE. Besides, through this reappraisal, the writers performed a broad hunt including a manual hunt in the chief gender diaries, mentions of mentions and contact with the experts on the subject. Randomized, controlled surveies of psychotherapeutics for PE are few, and the bulk have a little sample size. One-half of the included surveies was considered as low hazard of prejudice and the other half, moderate hazard. The aims of this reappraisal were: ( a ) determine whether psychosocial interventions were effectual for PE against placebo ( waiting list ) , ( B ) to measure if there was a different consequence between the types of psychosocial intervention and ( degree Celsius ) to measure the function of psychological intercession in concurrence with pharmacological intervention for bettering PE and ( vitamin D ) determine whether psychosocial interventions were effectual for PE compared with drug therapy. The new functional-sexological intervention ( including the squeezing and stop-start techniques ) and the traditional BT led to important betterments in the continuance of intercourse, sexual satisfaction, and sexual map compared with baseline and with the control group ( waiting list ) , but no difference between them were found. Traditional BT is established technique in the literature for PE and the functional-sexological intervention did non add any betterment in the results. While a general consensus exists that psychotherapeutics confers extra benefits on patients who use pharmacological therapy for PE ( Althof 2006 ) few comparative, controlled surveies have investigated the benefits of psychotherapeutics in combination with medicine in the intervention of this upset ( Melnik 2009a ) . By contrast, recent articles support the efficaciousness of combined intervention over pharmacotherapy or psychotherapy entirely for the intervention of PE. Furthermore, these surveies besides indicate that combination therapy consequences in a decreased rate of intervention discontinuance and improved satisfaction with intervention one of the most of import results in gender research. Restrictions of surveies of combination therapy include deficiency of description of healer features ( for illustration, professional preparation ) and of psychological techniques used. Fifty-one 2006 test showed that the combination of clomipramine and BT was superior than clomipramine en tirely related to the IELT, SAS and to the undermentioned inquiries of the CIPE questionnaire: ejaculatory latency ( inquiry 4 ) , control of ejaculatory physiological reaction ( inquiry 5 ) , patient sexual satisfaction ( inquiry 6 ) , spouse ‘s sexual satisfaction ( inquiry 7 ) and patient ‘s anxiousness in sexual activity ( inquiry 10 ) . After 1-month follow-up the IELT was statistically higher in combined group. Yuan 2008 test showed that the combined attack ( citalopram plus BT ) was non statistically different from citalopram entirely related with the betterment of IELT neither with the couple satisfaction with sexual life. The direct comparing between BT and citalopram showed important difference in betterment of IELT in favour A of drug therapy. However, this test was classified as moderate prejudice hazard and was non clear if the BT was applied by a psychologist or by a doctor ( Yuan 2008 ) . The pause-squeeze technique was associated with lower success rate ( sexual satisfaction tonss and IELT ) compared with Viagra and paroxetine, but the values were comparable to those achieved with clomipramine and Zoloft ( Abdel-Hamid 2001 ) . Restrictions of the surveies include deficiency of randomised controlled tests, consequence sizes that are non clearly clinically important, validated outcome assessment instruments as survey end points, deficiency of obliging follow-up informations bespeaking care of intervention consequences, and deficiency of intervention manuals that allow reproduction.Quality of the grounds AOne-half of the included surveies were considered a low hazard of prejudice and the other half, moderate hazard.Potential prejudices in the reappraisal procedure AFor both Chinese tests, the first writers were contact for extra informations, but with no answer. In the Yuan 2008 and Li 2006 tests informations about the allotment privacy was non adequately described.Agreements and dissensions with other surveies or reappraisals AThere is merely old published systematic reappraisal ( Melnik 2009 ) . However this reappraisal was carried out in 2008, besides included quasi-randomised surveies and did non present quantitative information analysis.Writers ‘ decisions ADeductions for pattern AFor people- with PE: There is A weak grounds of the benefitsA of psychosocial intercessions in combination with pharmacologic therapyA for PE and psychosocial therapy entirely. For clinicians- Overall, small grounds ( most surveies that demonstrate efficaciousness are non controlled or randomised and have limited followup ) shows that psychological intercessions are effectual in the intervention of PE. Randomized, controlled surveies of psychotherapeutics for PE are few, and the bulk employ a little sample sizes. One survey found a important betterment from baseline in the continuance of intercourse, sexual satisfaction and sexual map with new functional-sexological intervention and behaviour therapy compared to waiting list. One survey showed that the combination of Thorazine and BT was superior than Thorazine entirely. For policy shapers: -There is a demand for farther research to analyze psychosocial intercessions for PE. For laminitiss: – Funders with an involvement in psychosocial intercessions for PE should back up further adequately powered, and designed surveies. In order to be able to believe about the cost deductions of PE wellness services research is needed into the long term results and quality of life impactDeductions for research AGiven the heterogeneousness of patients with PE, research is needed to better understand peculiarly for patients with womb-to-tomb PE and no antiphonal patients. An option would be planing intercessions that address these different clinical features instead than merely look intoing chief effects of psychosexual interventions, research should turn to specific interactions between patient features and intervention modes. Tests should to boot mensurate several other of import results, including phases of motive and preparedness to alter, including increased sexual assurance, sexual satisfaction, increased familiarity, patient and spouse satisfaction, operation, and health-related quality of life ( Althof 2006 ) . The current usage of validated questionnaires may surely lend to a better cognition of certain psychological issues, such as the sum of self-pride, anxiousness, and depressive feelings ( Melnik 2009 ) . Some issues remain undiscovered ( Waldinger 2008 ) . For illustration, which psychological fundamental law makes work forces more vulnerable to endure psychologically from short IELTs and what are the psychological features of work forces who perceive themselves as enduring from PE while holding objectively long IELTs? Randomized tests with larger group samples tests are still needed to further research the current available grounds for psychological intercessions for handling PE. The tests should be conducted over a longer follow-up period to farther look into delayed effects of psychological intercessions. Furthermore, the elucidation of the optimum dosage and continuance of any psychosocial intervention besides still needs farther probe ( Althof 2010 ) . The techniques used for randomization, sightlessness ( judges blind ) and allocation privacy should be described clearly in presentation of a survey. In add-on, all results should be presented in figures every bit clear as possible in a manner that readers can analyze the informations and draw decisions themselves ( Melnik 2009 ) .AAs psychosocial intercessions are used for people with PE, big, simple, well-designed and reported tests are justified to set up whether they are effectual. Randomized tests with larger group samples tests are still needed to further research the current available grounds for psychological intercessions for handling PE. The tests should be conducted over a longer follow-up period to farther look into delayed effects of psychological intercessions. Research workers may wish to look into further the intercessions included in this reappraisal in the ways suggested or to research other psychosocial intercessions for PE. Further surveies of psychosocial intercessions for PE should include clinically meaningful results such as: A important alterations in satisfaction with sexual/ affectional relationship, mental province, backsliding, A battle with services, quality of life, go forthing the survey early, satisfaction with attention, societal operation, inauspicious effects, and economic results ( cost-effectiveness and cost-benefit ) . Finally, ongoing researches to extricate what are the most effectual constituents in psychosexual therapy. Should output information that will help in the defining and ordination of future intervention programmes in sexual researchA in a mode that will enable the delivering of the most cost effectual intervention to as much of the population as possible.A A A ARecognitions ATo the Prostatic and Urological Cancer Diseases for back uping and redacting this reappraisal.Contributions of writers ATamara Melnik – chief referee, protocol and reappraisal development, appraisal of surveies, hazard prejudice appraisal, updating. Rachel Riera – protocol and reappraisal development, appraisal of surveies, hazard prejudice appraisal. Maria Eduarda Santos Puga – hunt schemes Sidney Glina – protocol and reappraisal development Alvaro Nagib Atallah – critical assessment of concluding version Stanley E. Althof – critical assessment of concluding versionDeclarations of involvement ANone declaredDifferences between protocol and reappraisal ADue to the intercessions and results heterogeneousness, it was non possible to pool the informations and to execute meta-analysis as antecedently planned at protocol phase.

Animal Testing Essay

Animal Testing Essay Animal Testing Essay Animal testing has been going on for far too long. Whether it is to test a new cosmetic or develop another medication, scientists have used animals as a way of testing out new drugs and products before they are used on humans. Each year animals are blinded, force-fed, genetically altered, injured and more. They are kept in tiny, uncomfortable cages just to test something new. These innocent animals are hurt for science and the results might not even hold true for humans. While some may think that animals are not as developed as humans and use that argument to justify these experiments; Jeremy Bentham, a British philosopher, once said, â€Å"The question is not, ‘Can they reason?’ nor, ‘Can they talk?’ but rather, ‘can they suffer?’† Animals have been through too much suffering to sometimes benefit the lives of humans. Their deaths should not be considered acceptable simply because an occasional experiments has led to medical advancements. There are other options that we need to investigate. Testing on animals is unethical and should not be practiced under any circumstances. Some argue that animal testing has produced some benefits in the medical field. There have been numerous drugs proven though animal testing that have improved the lives of humans all over the world. From treatments for cancer to antibiotics for infection, without animal research, many of the medicines we use today would not exist. During animals testing, scientists are given a living laboratory in which to test their substance. For example, monkeys are often used in experiments because their bodies are so closely related to those of humans. Given that some believe we derived from monkeys, they are an obvious choice for testing. When monkeys are used to test a new pain medication, scientists observe the actions of the monkey before and after they have received the medication. Scientists cannot only see if the pain medication is working, but see if there are any side effects experienced by the monkey as well. From the responses, scientists are able to determine whether or not the medication would be suitable for a human being. By testing the medicine or product on an animal first, we ultimately save numerous human lives. This is not to say that animal’s lives are disregarded. Animal testing has certain rules to follow and regulations that protect the animal. The Animal Welfare Act became law in 1966 to regulate the treatment of animals in all conditions (â€Å"Animal Welfare Act†). Several groups and professionals such as the Animal and Plant Health Inspection Service enforce the act so that animals are protected during these experiments. Still, the benefits of animals testing do not outweigh the horrible tests being done on animals. The benefits of animal testing are often overstated and not well understood. PETA, a well-known organization for animal rights, corrects the misperception, â€Å"It’s bad sc ience. The Food and Drug Administration (FDA) reports that 92 out of every 100 drugs that pass animal tests fail in humans† (PETA). These appalling tests being done on innocent animals are not even producing accurate conclusions. In 1993 the FDA approved a drug called Propulsid (Pippin, and Sullivan). It was used to treat gastric reflex in children. After numerous tests on different animals such as mice and rabbits with no problems, the drug was released to the public (Pippin, and Sullivan). By 1995 people started noticing heart rhythm disturbances associated with the new drug. Many children and babies under one year of age were dying of heart disruptions (Pippin, and Sullivan). After 300 deaths, the drug was withdrawn from the medical market in 2000 (Pippin, and Sullivan). Vioxx is another drug that passed animals testing but was found lethal to humans. Vioxx was discovered as a pain medication for arthritis. It was tested on African green monkeys, mice, and rats and there we re no problems found (Gartner). However, when introduced to humans, the drug was found to

Understanding the Difference Between Lend and Loan

Understanding the Difference Between Lend and Loan In formal usage (especially in British English), lend is a verb and loan is a noun. In informal  American English, the use of loan as a verb is generally considered acceptable (particularly when it concerns the lending of money). See the usage notes below. Only lend has figurative uses, as in Lend me your ears or Lend me a hand.Also see:Commonly Confused Words: Loan and Lone Examples: Borrow trouble for yourself, if thats your nature, but dont lend it to your neighbors. (Rudyard Kipling)A bank, so the old saying goes, is a place where you can always get a loan- when you dont need one. Usage Notes Although most expert users of English dislike loan as a verb (I loaned him my pen), except in financial contexts, it must be acknowledged that the usage is sanctioned by dictionaries. If you are not offended by Friends, Romans, countrymen, loan me your ears or by Distance loans enchantment, you may go along with the dictionaries and you will always have a defense.(Theodore M. Bernstein, Miss Thistlebottoms Hobgoblins, Farrar, Straus and Giroux, 1971)Some people are bothered by the word loan as a verb, preferring to use lend in its place. Theres not much reason for the anxiety- loan has been a verb since around the year 1200, and I think an 800-year probation is long enough for anyone- but its now little used in America. My advice: dont be bothered by loan as a verb but, if you want to avoid irritating those who have this hangup, its never wrong to use lend.(Jack Lynch, The English Language: A Users Guide, Focus, 2008)The verb loan is well established in American usage and cannot be c onsidered incorrect. The frequent objections to the form by American grammarians may have originated from a provincial deference to British critics, who long ago labeled the usage a typical Americanism. Loan is, however, used to describe only physical transactions, as of money or goods; for figurative transactions, lend is correct: Distance lends enchantment. The allusions lend the work a classical tone.(The American Heritage Dictionary of the English Language, 4th ed., 2000) These are sometimes interchangeable, sometimes not. Only lend carries the figurative senses of adding or giving, as in lend strength to the cause or lend color to an otherwise routine event. But for other senses, as when property or money pass temporarily from one owner to another, either word could be used. . . . In American and Australian English, the verb loan is readily used as an alternative to lend in such applicationsbut not so much in contemporary British English. The word was used in Britain up to C17, but a curious resistance seems to have developed there during C18 and C19, when the Oxford Dictionary (1989) citations are all from the US, and the word somehow acquired provincial associations. Fowler (1926) noted that it had been expelled from southern British English, but that it was still used locally in the UK. Yet Gowers writing after World War II found it returning to British government writing (1948, 1954) and weighs in against it in his 1965 edition of Fowler as a nee dless variant (1965). This seems to be the basis on which British usage commentators argue that loan must be used only as a noun (except in banking and finance) and lend as a verb. Some British dictionaries (Collins, 1991) and the Canadian Oxford (1998) still echo the inhibition, while data from the BNC [British National Corpus] shows that many British writers are comfortable with it. (Pam Peters, The Cambridge Guide to English Usage, Cambridge University Press, 2004) Practice   (a) Never _____ your car to anyone to whom you have given birth.(Erma Bombeck)(b) Gus asked Merdine for a _____. Answers to Practice Exercises (a) Never  lend  your car to anyone to whom you have given birth. (Erma Bombeck)(b) Gus asked  Merdine  for a  loan.

Pol Pot essays

Pol Pot essays On April 17, 1976, Pol Pot and the Khmer Rouge, a group of Cambodian Marxists, stormed the Cambodian capital of Phonm Penh, forcing Cambodia into four years of horrifying terror. They declared this time Zero Hour, the day Cambodia would enter a new utopian era and say goodbye to the flawed ways of a capitalistic society. Yet in reality, Pol Pot, leader of the Khmer Rouge, achieved nothing for Cambodia. The Cambodian people only suffered under Pol Pot, with an estimated death toll of 3,000,000. Pol Pot, a conniving man, whos rule over Cambodia was marked by mass murder, negligence, and despotic rule, attempted and failed to create an egalitarian communist society, exploiting the manual power of the masses. In 1970, Prince Sihanouk was hoisted out of power in a coup de tat. General Lon Nol, backed by the Central Intelligence Agency (CIA) of the United States (US), successfully seized power in Cambodia. Nol, as opposed to Sihanouk, was pro US, something the US valued in their war against Cambodias bordering nation of Vietnam. Nol took little consideration of the people and their needs, and his corrupt administration stirred support for the Khmer Rouge (Seekins, 4). At that time, the Khmer Rouge, a thirty-year-old Communist movement, began their take over of Cambodia. In the five-year period that followed, Cambodia befell into a Civil War between the Khmer Rouge and Lon Nols forces. On April 17th, 1976, the Khmer Rouge succeeded and marched into Phnom Penh. The Khmer Rouge, at the time, was led by Pol Pot, formerly known as Saloth Sar. Sar had received an education in radio electronics in France. In France, Sar was introduced to Marxism. His teachers led him to believe that Cambodia, a prosperous monarchy at the time, should go through an agricultural revolution, converting Cambodia to a classless agrarian country (Geyer, 1). In doing so, Pol Pot was believed that Cambod...